CLINICAL TRIALS AND OBSERVATIONS Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children’s Oncology Group
نویسندگان
چکیده
1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2Division of Pediatric Hematology/Oncology, University of Washington School of Medicine, Seattle; 3Children’s Oncology Group, Arcadia, CA; 4Department of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles; 5Division of Medical Oncology, Seattle Cancer Care Alliance/University of Washington School of Medicine; 6Department of Pathology, The Ohio State University, Columbus; 7Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN; 8Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis; 9Department of Pediatrics, University of Southern California, Los Angeles; 10Amgen Incorporated, Thousand Oaks, CA; and 11The Children’s Hospital of Philadelphia, PA
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
To evaluate the incidence and clinical impact of WT1 gene mutations in younger adult patients with cytogenetically normal acute myeloid leukemia (CN-AML), sequencing of the complete coding region was performed in diagnostic samples from 617 patients who were treated on 3 German-Austrian AML Study Group protocols. WT1 mutations were identified in 78 (12.6%) of the 617 patients; mutations cluster...
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1Division of Hematology/Oncology/BMT, BC’s Children’s Hospital, Vancouver, BC, Canada; 2Department of Preventive Medicine, University of Southern California, Los Angeles; 3Children’s Oncology Group, Arcadia, CA; 4Fred Hutchinson Cancer Research Center, Seattle, WA; 5Department of Pathology, Ohio State University, Columbus; 6Division of Pediatric Hematology/Oncology, IWK Health Center, Halifax, ...
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Activating mutations of the FLT3 gene occur because of an internal tandem duplication of the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain (FLT3/ALM). The presence of FLT3 mutations as well as the allelic ratio of FLT3/ITD (ITD-AR, mutant– wild type ratio) may have prognostic significance. FLT3 mutation status of 630 children with de novo acute myeloid leukemi...
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1Division of Pediatric Oncology, City of Hope National Medical Center, Duarte, CA; 2Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles; 3Children’s Oncology Group, Arcadia, CA; 4Department of Pathology, Johns Hopkins Medical Center, Baltimore, MD; 5Department of Pathology, Phoenix Children’s Hospital, AZ; 6Department and Division of Pediat...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia
1Pediatric Hematology and Oncology, University of Frankfurt, Germany; 2Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany; 3Children’s Cancer Research Institute, St Anna Kinderspital and Children’s Cancer Research Institute (CCRI), Vienna, Austria; 42nd Medical School, Charles University, Prague, Czech Republic; 5Department of Pediatric Hematology and Oncology, Un...
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تاریخ انتشار 2010